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| Barbosa-Filho,José Maria; Sampaio A Lima,Cláudia; Camorim,Elba Lúcia; de Sena,Kêsia Xisto FR; Almeida,Jackson Roberto GS; Vasconcelos L da-Cunha,Emídio; Silva,Marcelo S; Agra,Maria de Fátima; Braz-Filho,Raimundo. |
| We report morphodiagnosis, and phytochemical and antimicrobial investigations of Tabebuia aurea. It was noted that the leaves are compostas with anomocytic stomata only on the lower side; the vascular system is concentric andthe mesophyll arrangement is dorsiventral. From the stem bark eight compounds were isolated, including: lapachol, 3,4',5-trihydroxy-7-methoxyflavone, b-sitosterol, betulinic acid, p-anisic acid, veratric acid, methyl cinnamate and ethyl p-hydroxy-cinnamate. Antimicrobial assays showed growth inhibition the of Gram positive and Gram negative bacteria, alcohol-acid bacterium and fungi. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tabebuia aurea; Bignoniaceae; Pharmacobotany; Lapachol; Chemical constituents; Antimicrobial activity. |
| Ano: 2004 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-56572004000100027 |
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| Esteves-Souza,A.; Figueiredo,D.V.; Esteves,A.; Câmara,C.A.; Vargas,M.D.; Pinto,A.C.; Echevarria,A.. |
| The cytotoxic activity of amino (3a-e), aza-1-antraquinone (4a-e) lapachol derivatives against Ehrlich carcinoma and human K562 leukemia cells was investigated. Cell viability was determined using MTT assay, after 48 (Ehrlich) or 96 h (K562) of culture, and vincristine (for K562 leukemia) and quercetin (for Ehrlich carcinoma) were used as positive controls. The results showed dose-dependent growth-inhibiting activities and that the amino derivatives were active against the assayed cells, whereas the 4a-e derivatives were not. The allylamine derivative 3a was the most active against Ehrlich carcinoma, with IC50 = 16.94 ± 1.25 µM, and against K562 leukemia, with IC50 = 14.11 ± 1.39 µM. The analogous lawsone derivative, 5a, was also active against Ehrlich... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Lapachol; Amino-lapachol derivatives; Cytotoxicity; DNA-topoisomerase; DNA-interactions. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001000013 |
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| Maganha,Juliana; Rocha,Evelise de Souza; Brandão,Marcos Antônio Fernandes; Peters,Vera Maria; Guerra,Martha de Oliveira. |
| Lapachol, a naphthoquinone extracted from plants of the genus Tabebuia (family Bignoneaceae), showed multiple therapeutic activities. Pregnant Wistar rats were treated with Lapachol from the 1st to the 4th (pre-implantation period) and from 5th to 7th (implantation period) post insemination day (PID). Mothers were sacrificed on the 5th or on the15th PID. Number of corpora lutea, preimplantation embryo, blastocysts, live and dead fetuses and resorptions were counted. There were no signs of maternal toxicity. The number and the morphology of embryos, during oviduct development (pre-implantation period), did not seem to be affected by this drug, but during the implantation period, lapachol was toxic causing the death of embryos and intrauterine growth... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lapachol; Embryo development; Rat; Reproductive toxicity. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000700010 |
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| OLIVEIRA,MAILCAR F.; LEMOS,TELMA L.G.; MATTOS,MARCOS C. DE; SEGUNDO,TACIANA A.; SANTIAGO,GILVANDETE M.P.; BRAZ-FILHO,RAIMUNDO. |
| A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lapachol; Enamine derivatives; Biological activities. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200004 |
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| FUTURO,DÉBORA O.; FERREIRA,PATRICIA G.; NICOLETTI,CAROLINE D.; BORBA-SANTOS,LUANA P.; SILVA,FERNANDO C. DA; ROZENTAL,SONIA; FERREIRA,VITOR FRANCISCO. |
| ABSTRACT Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quinones; Xanthenes; Lapachol; Lawsone; Candida spp; Disc diffusion method. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301187 |
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| GUERRA,M. de O.; MAZONI,A. S. B.; BRANDÃO,M. A. F.; PETERS,V. M.. |
| Lapachol is a naphtoquinone with therapeutic potential against enterovirus, Chagas disease and is also used as an antimalarial and antiinflamatory agent. In order to study teratogenic potential of Lapachol, pregnant Wistar rats were treated with 0.5 ml of distilled water (control group); 0.5 ml of hydroalcoholic solution (vehicle group) and 10 mg of Lapachol in 0.5 ml of hydroalcoholic solution (treated group) by oral gavage from the 8th to the 12th day of pregnancy. The following variables were observed: maternal body weight on days 1, 6, l5 and 21 and food intake on days 2, 6, 15 and 21 of pregnancy. The number of live and dead fetuses and the sites of resorptions were counted. The ovaries were weighed and the corpora lutea were counted. Data were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lapachol; Embryotoxicity; Rat. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71082001000100021 |
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